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. 2021 Jan 26;11:616141. doi: 10.3389/fimmu.2020.616141

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Copyright © 2021 Hiramatsu-Asano, Sunahori-Watanabe, Zeggar, Katsuyama, Mukai, Morita and Wada

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Exacerbation of lupus nephritis in B6-Mir223⁻^/⁻Fas^lpr/lpr mice. (A) Representative kidney sections from B6-Mir223⁻^/⁻Fas^lpr/lpr and B6-Mir223^+/+Fas^lpr/lpr mice, stained with periodic acid–Schiff (PAS). Bars = 50 µm. (B) Score distribution of glomerular, renal vascular and tubulointerstitial lesions in B6-Mir223⁻^/⁻Fas^lpr/lpr compared to B6-Mir223^+/+Fas^lpr/lpr mice (n = 10 per group). Data are presented as mean ± SEM. ***p < 0.001, ns, not significant, by Pearson’s χ2 test in (B).