Figure 6.

Glomerulonephritis with infiltration of CD4⁺S1PR1⁺ T cells in in B6-Mir223^−/−Fas^lpr/lpr (A) The image of CD4⁺ cells, CD4⁺S1PR1⁺ cells, CD8⁺ cells and CD8⁺S1PR1⁺ cells in glomerular lesion in B6-Mir223^−/−Fas^lpr/lpr compared to B6-Mir223^+/+Fas^lpr/lpr mice (n = 5 per group). Images are representative of five mice per group. Bars = 50 µm. (B) The number of CD4⁺ cells, CD4⁺S1PR1⁺ cells, CD8⁺ cells and CD8⁺S1PR1⁺ cells in glomerulus or tubular lesion in B6-Mir223^−/−Fas^lpr/lpr compared to B6-Mir223^+/+Fas^lpr/lpr mice (n = 5 per group). Data are presented as mean ± SEM. *p < 0.05, **p < 0.01, ns, not significant, by Student’s t-test in (B).