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. 2021 Jan 26;11:627838. doi: 10.3389/fphar.2020.627838

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Copyright © 2021 Boknik, Escandar, Hofmann, Zimmermann, Neumann and Gergs.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic cardiac conducting system and regional adenosine receptor expression in the heart (modified from Stein et al., 1998). The anatomical localization of the sinus node (SA), the AV node (AV) the bundle of His (His). The Purkinje fibers (Purkinje) and the work generating muscle cells in the atrium and the ventricle are depicted. In these structures A_2A-ARs were functionally and/or biochemically detected. Their stimulation can explain the functional consequence listed in the adjoining table.