TABLE 3.

A_2A-adenosine receptor antagonists.

Antagonist aname	Ki nM	Indications	References
Theophylline	1710		Fredholm et al. (2011)
Caffeine	9,560–23,400		Fredholm et al. (2011)
Istradefylline	2–91	M. Parkinson	Fredholm et al. (2011), Cacciari et al. (2018)
Tozadenant	5	M. Parkinson	Cacciari et al. (2018)
ZM 241385	0.8		Cacciari et al. (2018)
MSX-2	5–8.0		Fredholm et al. (2011), Cacciari et al. (2018)
SCH 58261	1.1–5		Fredholm et al. (2011), Cacciari et al. (2018)
SCH 442416	0.048–4.1		Fredholm et al. (2011), Cacciari et al. (2018)
Preladenant	0.9–1.1	M. Parkinson	Fredholm et al. (2011), Cacciari et al. (2018)
Vipadenant	1.3	M. Parkinson	Cacciari et al. (2018)
ST 1535	6.6–11		Fredholm et al. (2011), Cacciari et al. (2018)
ST 4206	9		Cacciari et al. (2018)
CGS 15943	1.2		Fredholm et al. (2011)
CSC	54		Fredholm et al. (2011)
V2006	1.3		Fredholm et al. (2011)

The range of Ki values is probably due to species differences and small difference in methodology.