TABLE 4.

A_2A-adenosine receptor: Signal transduction.

Signal	Species/cell type		References
PP2A		Inhibition	Tikh et al. (2008)
PP1		Translocation and activation	Revan et al. (1996)
	Dermal fibroblasts
Thrombin induced ERK phosphorylation		Inhibits	Hirano et al. (1996)
Gs			Kull et al. (2000), Fenton and Dobson (2007)
PI kinase			Schulte and Fredholm (2000), Boucher et al. (2004)
Ca2+	Increased		Woodiwiss et al. (1999)
Actinin			Burgueño et al. (2003)
Ca sensitivity	Increased		Woodiwiss et al. (1999)
Phospho erk	Increased	Mouse heart	Ribé et al. (2008)
Phospho-p-38	Increased	Mouse heart	Ribé et al. (2008)
Phospho-JNK	Increased	Mouse heart	Ribé et al. (2008)
Free radicals	Reduced	Mouse heart	Ribé et al. (2008)
Ca2+ sparks	Increased	Atrial human cardiomyocytes	Llach et al. (2011)
CREB phosphorylation	Increased	Leukocytes	Koshiba et al. (1999), review: Rabadi and Lee (2015)
Free radicals	Reduced	Neutrophils	Jordan et al. (1997)
Epac	Activated	Dermal fibroblasts	Perez-Aso et al. (2013)