TABLE 7.

A_2A-adenosine receptor sensitization and desensitization.

Agonist/Intervention	Tissue	Read out		References
NECA	Relaxation of coronary bovine arteries	Force	Desensitization	Conti et al. (1997)
NECA	DD1 MF cells	cAMP	Desensitization	Ramkumar et al. (1991)
NECA	PC12 cells	cAMP	Desensitization	Chern et al. (1993)
Hypoxia	Pulmonary endothelial cells	A2A-AR mRNA	Sensitization	Ahmad et al. (2009)
Caffeine	Platelets	A2A-AR radio-ligand binding	Sensitization	Varani et al. (1999)
LPS
Diazepam	Rat pulmonary arteries	Relaxation		Ujfalusi et al. (1999)
D2 receptor stimulation	Neuroblastoma cells	cAMP		Vortherms and Watts (2004)