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. Author manuscript; available in PMC: 2021 Apr 20.
Published in final edited form as: Acc Chem Res. 2020 Oct 5;53(10):2094–2105. doi: 10.1021/acs.accounts.0c00456

Figure 1.

Figure 1.

(A) sHDL nanodiscs, composed of phospholipids and apolipoprotein-1 mimetic peptides (22A), are coloaded with cysteine-modified tumor-specific mutated neoantigen peptides and CpG, an immunostimulatory adjuvant. (B) Immunization scheme of MC-38 study with nanodiscs. (C and D) Tumor growth curves of mice vaccinated with sHDL nanodiscs with or without anti-PD-1 IgG therapy. (E) Frequency of neoantigen-specific CD8+ T cells among PBMCs. Reproduced with permission from ref 1. Copyright 2017 Nature Publishing Group.