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. 2020 Oct 18;246(2):240–248. doi: 10.1177/1535370220963755

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Figure 4. — Transmission electron micrographs and electrophysiology recordings of hRPE 252 cells converted by ASCL1 and miRNA124. (a, b) Transmission electron micrographs of hRPE 252 cells reprogrammed with ASCL1 and miRNA124 for 10 days. Arrowheads, photoreceptor disc-like structures. Scale bars: 500 nm in (a), 100 nm in (b). (c) In response to voltage steps, small voltage-gated Na⁺ currents (I_Na⁺, inward) and voltage-gated delayed rectifier K⁺ currents (I_K⁺, outward) were recorded in hRPE 252 cells reprogrammed with ASCL1 and miRNA124 for seven days. (d) In response to voltage steps, large voltage-gated Na⁺ currents (I_Na⁺, inward), voltage-gated A-type K⁺ currents (I_K⁺, outward), and voltage-gated Ca²⁺ currents (I_Ca²⁺, inward) were recorded in hRPE 252 cells reprogrammed with ASCL1 and miRNA124 for 14 days.