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Acute administration of 40 mg/kg (±)-1 time-dependently reverses CCI-induced mechanical sensitivity in ipsilateral and contralateral paws. Data are expressed as mean ± SEM (n = 8/group). ****p < 0.0001, *p < 0.05 vs sham + vehicle; ###p < 0.001 ##p < 0.01, #p < 0.05 vs CCI + vehicle. pre-sx (pre-surgery); post-sx (post-surgery).
