Table 1.
Mutant Fractions of Different Classes of Mutations Induced by NNN, DB[a,l]P, and Their Combination in the Tongue of lacI Mice
| NNN | DB[a,l]Pa | DB[a,l]P + NNN (obs.)b | DB[a,l]P + NNN (exp.)b | |||||
|---|---|---|---|---|---|---|---|---|
| class | mutants | MF × 10−5 | mutants | MF × 10−5 | mutants | MF × 10−5 | mutants | MF × 10−5 |
| G:A | 9 | 0.49 | 7 | 0.93 | 21 | 5.12d | 16 | 1.42 |
| G:T | 8 | 0.44 | 14 | 1.81 | 7 | 1.71 | 22 | 2.24 |
| G:C | 5 | 0.27 | 3 | 0.38 | 8 | 1.95 | 8 | 0.65 |
| A:G | 5 | 0.27 | 3 | 0.38 | 1 | 0.24 | 8 | 0.65 |
| A:C | 2 | 0.11 | 4 | 0.55 | 2 | 0.49 | 6 | 0.66 |
| A:T | 15 | 0.82 | 6 | 0.77 | 6 | 1.46 | 21 | 1.58 |
| indelc | 5 | 0.33 | 5 | 0.66 | 5 | 1.22 | 10 | 0.98 |
| 49 | 2.72 | 42 | 5.47 | 50 | 12.2 | 91 | 8.19 | |
a
Results from DB[a,l]P were taken from ref 7.
b
Obs. and exp. mutations in each class of mutation were compared using a Fisher’s exact test. There were three redundant mutations in the NNN group and two in the NNN + DB[a,l]P group. Three samples failed to yield a readable sequence.
c
indel, insertion or deletion.
d
p < 0.05 versus DB[a,l]P + NNN expected.