Table 3. Associations Between PPI Use and Risk for Asthma, Stratified by Cumulative Duration of PPI Use.
| Initiation status | Person-years (% of total person-years) | No. of events | Incidence ratea | Absolute risk difference in incidence (95% CI)a | HR (95% CI) |
|---|---|---|---|---|---|
| None | 201 971.1 (100) | 2818 | 14.0 | 1 [Reference] | 1 [Reference] |
| Time since initiation, d | |||||
| ≤30 | 111 331.6 (55) | 2419 | 21.7 | 7.8 (6.8-8.8) | 1.52 (1.44-1.61) |
| 31-364 | 88 829.9 (44) | 1939 | 21.8 | 7.9 (6.8-9.0) | 1.51 (1.42-1.60) |
| ≥365 | 2707.9 (1) | 70 | 25.9 | 11.9 (5.8-18.0) | 1.59 (1.25-2.02) |
Abbreviations: HR, hazard ratio; PPI, proton pump inhibitor.
a
Calculated as events per 1000 person-years.