Table 1.

Major Methyltransferases and Demethylases of Lysines in Histone 3 and 4.

	H3K4	H3K9	H3K27	H3K36	H3K79	H4K20
Methyltransferases	MLL1 (KMT2A) MLL2 (KMT2B) MLL3 (KMT2C) MLL4 (KMT2D) MLL5 (KMT2E) SET1A (KMT2F) SET1B (KMT2G) SETD7 (KMT7) SMYD1 (KMT3D) SMYD2 (KMT3C) SMYD3 (KMT3E) ASH1L (KMT2H) SETD3 SETMAR	SETDB1 (KMT1E) SETDB2 (KMT1F) SUV39H1 (KMT1A) SUV39H2 (KMT1B) EHMT1 (KMT1D) EHMT2 (KMT1C) PRDM2 (KMT8)	EZH2 (KMT6)	SETD2 (KMT3A) NSD1 (KMT3B) WHSC1 (NSD2) WHSC1L1 (NSD3) ASH1L (KMT2H) SETD3 SETMAR	DOTH (KMT4)	SETD8 (KMT5A) SUV420H1(KMT5B) SUV420H2 (KMT5C) NSD1 (KMT3B)
Demethylases	KDM1A (LSD1) KDM1B (LSD2) KDM2B (JHDM1B) KDM5A (JARID1A) KDM5B (JARID1B) KDM5C (JARID1C) KDM5D (JARID1D) C14orf169 (RIOX1)	KDM1A (LSD1) KDM3A (JHDM2A) KDM3B (JHDM2B) KDM4A (JHDM3A) KDM4B (JMJD2B) KDM4C (JMJD2C) KDM4D (JMJD2D) KDM7A (JHDM1D) PHF8 (KDM7B)	KDM6A (UTX) KDM6B (JMJD3) PHF8 (KDM7B) KDM7A (JHDM1D)	KDM2A (JHDM1A) KDM2B (JHDM1B) KDM4A (JHDM3A) KDM4C (JMJD2C) C14orf169 (RIOX1)	/	KDM7A (JHDM1D) PHF8 (KDM7B)