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. 2020 Jun 4;34(1):149–162. doi: 10.1177/0897190020927274

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© The Author(s) 2020

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 1. — Stepwise approach to control symptoms and minimize risk of future exacerbations in adults and adolescents 12 years and older with asthma as per GINA.¹³ For children 6-11 years, the preferred Step 3 treatment is low dose ICS-LABA or medium dose ICS. *Off-label; data only with budesonide-formoterol ^†Off-label; separate or combination ICS and SABA inhalers. ^‡Low dose ICS-formoterol is the reliever for patients prescribed budesonide-formoterol or BDP-formoterol maintenance and reliever therapy. ^#Consider adding HDM SLIT for sensitized patients with allergic rhinitis and FEV₁ >70% predicted. BDP indicates beclomethasone dipropionate; FEV₁, forced expiratory volume in 1 second; GINA, Global Initiative for Asthma; HDM SLIT, house dust mites–sublingual immunotherapy; ICS, inhaled corticosteroids; IgE, immunoglobulin E; IL, interleukin; LABA, long-acting β₂-agonist; LTRA, leukotriene receptor antagonist; OCS, oral corticosteroids; SABA, short-acting β₂-agonist. Note: Reused with permission from Global Initiative for Asthma pocket guide 2019 (©: 2019 Global Initiative for Asthma, Inc.).