Table 4.

Reliability and responsiveness of the NRS questions of RAID from the rainbow study

RAID NRS	Screening	Baseline (2 weeks after screening)	12 weeks (after baseline)	Reliability screening baseline (ICC, 95% CI) (n=108)	Sensitive to change baseline 12 weeks (SRM, 95% CI) (n=97)
Tender joint count	10.3 (5.9)	10.7 (5.8)	4.2 (4.8)	0.90 (0.85 to 0.93)	1.18 (0.90 to 1.38)
Swollen Joint Count	8.2 (9.8)	8.6 (4.1)	2.3 (2.6)	0.89 (0.83 to 0.92)	1.82 (1.59 to 2.05)
PGA	6.6 (1.7)	6.5 (1.9)	3.3 (2.3)	0.63 (0.50 to 0.73)	1.35 (1.01 to 1.63)
DAS28(3 v)-ESR	5.1 (0.8)	5.1 (0.8)	3.3 (1.1)	0.93 (0.90 to 0.95)	1.80 (1.50 to 2.10)
Pain	6.6 (1.8)	6.5 (1.8)	3.1 (2.3)	0.64 (0.51 to 0.74)	1.34 (1.01 to 1.64)
Function	6.4 (1.9)	6.3 (2.0)	3.2 (2.4)	0.69 (0.58 to 0.78)	1.21 (0.89 to 1.49)
Fatigue	6.4 (2.3)	6.2 (2.3)	3.4 (2.7)	0.80 (0.72 to 0.86)	1.16 (0.89 to 1.36)
Emotional Well-being	5.5 (2.5)	5.3 (2.4)	2.8 (2.4)	0.75 (0.65 to 0.82)	1.04 (0.79 to 1.26)
Physical Well-being	6.3 (2.0)	6.2 (1.9)	3.1 (2.5)	0.78 (0.70 to 0.85)	1.25 (0.97 to 1.50)
Sleep Disturbance	5.3 (2.9)	5.5 (2.8)	2.9 (2.7)	0.83 (0.76 to 0.88)	0.93 (0.73 to 1.13)
Coping	4.9 (2.2)	4.8 (2.0)	2.6 (2.2)	0.64 (0.52 to 0.74)	0.97 (0.63 to 1.22)

Results are presented as Mean (SD) at each time point. CI obtained through bootstrapping method. ICC >0.8 was considered excellent. SRM >0.8 was considered as responsive.

DAS28(3v)-ESR, Disease activity Score, 3 variables with erythrocyte sedimentation rate; ICC, intra-class correlation; NRS, numerical rating scale; PGA, patient global assessment; SRM, standardised response mean.