Figure 4.

Circ_0003998 knockdown regulated DTX-resistant NSCLC cell colony formation, apoptosis and DTX sensitivity in vitro by miR-136-5p. A549/DTX and H1299/DTX cells were transfected with si-NC, si-circ (si-circ_0003998), si-circ+inhibitor NC or si-circ+miR-136-5p inhibitor for 48 h, followed by the determination of miR-136-5p expression by qRT-PCR (A), cell viability by CCK-8 assay (B), cell colony formation by colony formation assay (C), cell apoptosis by flow cytometry (D), the levels of PCNA, P-gp, MRP1 and bax by western blot (E). *P < 0.05, **P < 0.01 or ***P < 0.001.