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. 2021 Jan 29;20:1533033821990040. doi: 10.1177/1533033821990040

Figure 5.

Figure 5.

MiR-136-5p directly targeted the 3′UTR of CORO1C. CORO1C mRNA and protein levels by qRT-PCR and western blot in primary NSCLC tissues (sensitive/S), recurrent NSCLC tissues (resistant/R) and matched healthy lung tissues (normal/N) (A and B), 16HBE, A549, H1299, A549/DTX and H1299/DTX cells (C and D). (E) Correlation between CORO1C mRNA expression and miR-136-5p level in 50 NSCLC tissues using Spearman test. (F) Schematic of the potential miR-136-5p target sequence within the 3′UTR of CORO1C and mutated target sequence. (G) Dual-luciferase assays in 293 T cells cotransfected with CORO1C 3′UTR wt or CORO1C 3′UTR mut and mimic NC or miR-136-5p mimic. **P < 0.01, ***P < 0.001 or ### P < 0.001.