Figure 6.

The effect of miR-136-5p overexpression on DTX-resistant NSCLC cell colony formation, apoptosis and DTX sensitivity in vitro was mediated by CORO1C. A549/DTX and H1299/DTX cells were transfected with mimic NC, miR-136-5p mimic, miR-136-5p mimic+vector or miR-136-5p mimic+oe-CORO1C for 48 h, followed by the detection of CORO1C mRNA and protein levels by qRT-PCR and western blot (A-D), cell viability by CCK-8 assay (E), cell colony formation by colony formation assay (F), cell apoptosis by flow cytometry (G), the levels of PCNA, P-gp, MRP1 and bax by western blot (H). *P < 0.05, **P < 0.01 or ***P < 0.001.