Table 2. Total numbers of congenital anomalies, numbers in those live born and prevalence per 10,000 live born in ALSPAC-G1 participants (total N live born = 14,791 of the 14,869 enrolled and linkable [see Figure 1]).
| Anomaly subtype a | Total N (N
born alive) b |
Prevalence per
10,000 live births |
EUROCAT prevalence
per 10,000 live births 23 |
|---|---|---|---|
| Any CA | 590 (570) | 385.3 | 205.7 |
| CHD | 127 (119) | 80.5 | 56.0 |
| Nervous system | 18 (15) | 10.1 | 13.5 |
| Respiratory | 5 (5) | 3.4 | 1.9 |
| Orofacial clefts | 16 (16) | 10.8 | 14.2 |
| Eye | 29 (29) | 19.6 | 5.6 |
| Ear, face, neck | * | * | 5.7 |
| Digestive system | 16 (14) | 9.5 | 20.3 |
| ABWD | * | * | 2.7 |
| Urinary | 48 (44) | 29.7 | 28.6 |
| Genital | 64 (64) | 43.3 | 10.9 |
| Limb | 197 (196) | 132.5 | 48.4 |
| Other | 60 (57) | 38.5 | - |
| Chromosomal | 42 (39) | 26.4 | 15.8 |
| Teratogenic/genetic
syndromes, microdeletions and chromosomal abnormalities |
67 (63) | 42.6 | - |
Abbreviations: CA, congenital anomaly; CHD, congenital heart disease; ABWD, abdominal wall defects; ABWD, abdominal wall defects; * used when there were fewer than 5 cases in a given category all of these would have prevalence per 10,000 <3.4. a ICD codes used to define subtypes can be found in the Extended data 18. b We have included all cases in ALSPAC including whether they resulted in a fetal death. We give the number live born in brackets and this is used to estimate live born prevalence for comparison with EUROCAT results. Minor anomalies according to EUROCAT are not included. Numbers represent cases of congenital anomalies; if a child had multiple anomalies affecting different systems, they would contribute to more than one category. Each child could contribute to each category once.