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. 2021 Jan 3;162(4):bqaa249. doi: 10.1210/endocr/bqaa249

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© The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Schematic of the regulatory elements within the hPRL pituitary and extra-pituitary promoter regions. Schematic of the hPRL promoter illustrating pituitary and extra-pituitary regions (A). Response elements within the pituitary promoter that enable expression of PRL in the pituitary (adapted from (4)) (B). Response elements within the extra-pituitary region that enable expression of PRL in extra-pituitary tissues (including information from (38)) (C). Schematic of the hPRL-Luc 160 kb BAC expressing luciferase under the control of the entire hPRL gene (D). Abbreviations: AP1, activator protein 1; cEBPβ, CCAAT binding protein beta; CRE, cAMP response element; ER, estrogen receptor; FOXO1A, forkhead box protein O1A; GR, glucocorticoid receptor; HNF-3, hepatocyte nuclear factor 3; NFκB, nuclear factor kappa-light-chain-enhancer of activated B cells; NF-Y, nuclear factor Y; PR, progesterone receptor; TGIF, TG-interacting factor; TRF, TBP (TATA binding protein)-related factor.