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. 2021 Feb 8;21:55. doi: 10.1186/s12876-021-01633-8

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — ANGP-2 expression in the plasma of CHC patients. a, b Plasma ANGP-2 and ET-1 levels in CHC patients (HCV (+)) were determined using ELISA and compared to those in healthy volunteers (HV) (left panels). The effects of eradication were examined (right panels). c Collagen deposition was assessed by Sirius Red staining. CD31 expression in the liver was examined by immunohistochemistry (original magnification: × 40). d Correlation of the plasma ANGP-2 level with the Sirius Red-positive area in the liver, F-stage, serum M2BPGi, VTQ, LSM, platelet count, prothrombin time, serum albumin, and ALBI score are shown. e Correlation of the CD31-positive area in the liver with the plasma ANGP-2 level and Sirius Red-positive area are shown. The results are provided as means ± SDs. *P < 0.05 based on a two-tailed Student’s t-test. The values for Spearman’s or Pearson’s correlation coefficient are indicated