Fig. 7.

SLCP treatment preserved dendritic spine-signaling markers in PFC and hippocampus of 5xFAD mice. Six- and 12-month-old 5xFAD and age-matched control mice were treated with SLCP (100 mg/kg) for 2 months and then their brains were extracted, and cortical and hippocampal tissue homogenates were processed for Western blot analyses using antibody probes for selected proteins. a Representative Western blots from cortical and hippocampal tissue in 5xFAD mice, with or without treatment with SLCP. b–g Optical densitometric measures from 3 to 4 blots from each protein sample were made. Note that Shank, Homer, Drebrin, pCREB, and total CREB were significantly reduced in vehicle-treated 5xFAD mice and that SLCP treatments partially preserved these levels. *p < 0.05 in comparison to WT + vehicle, 5xFAD + SLCP, and WT + SLCP