Table 5.

Percentage reduction of dendritic spine density in PFC, CA1, CA3, and EC areas in vehicle-treated 5xFAD and 5xFAD treated with SLCP in comparison to age-matched WT mice. 6-m 6-month-old, 12-m 12-month-old. *p < 0.05 and **p < 0.01 when compared with vehicle-treated 5xFAD mice

Areas	Groups	Apical branch				Basal branch
		Primary branch		Secondary branch		Primary branch		Secondary branch
		6-m	12-m	6-m	12-m	6-m	12-m	6-m	12-m
PFC	5xFAD + vehicle	47.70	66.45	50.83	61.93	42.34	61.48	62.13	56.87
	5xFAD + SLCP	21.66**	30.32**	16.71**	31.55**	27.35**	27.48**	30.06	17.09**
CA1	5xFAD + vehicle	41.88	48.71	45.13	58.58	24.64	47.00	30.86	61.96
	5xFAD + SLCP	29.22	20.62**	8.91**	33.18**	8.09**	31.50*	12.67*	29.67**
CA3	5xFAD + vehicle	57.03	67.52	53.49	71.12	30.86	72.84	31.32	60.60
	5xFAD + SLCP	33.76**	43.92**	38.10*	39.42**	9.25	24.85**	14.37	20.12**
EC	5xFAD + vehicle	45.67	48.50	43.72	49.18	37.87	45.12	35.99	62.46
	5xFAD + SLCP	28.86**	37.78	21.24*	35.20*	20.49*	1.65**	16.21*	31.80**