Table 2.

Correlation between C3AR1 and immune markers in STAD by TIMER and GEPIA database.

Description	Gene markers	TIMER		GEPIA
		r	P-value	r	P-value
CD8+T Cell	CD8A	0.552	***	0.57	***
	CD8B	0.342	***	0.37	***
B Cell	CD19	0.285	***	0.24	***
	CD79A	0.373	***	0.34	***
Monocyte	CD86	0.909	***	0.92	***
	CD115(CSF1R)	0.902	***	0.9	***
TAMs	CCL2	0.522	***	0.55	***
	CD68	0.661	***	0.73	***
	IL10	0.704	***	0.75	***
M1 macrophage	INOS(NOS2)	0.113	*	0.15	**
	IRF5	0.342	***	0.4	***
	COX2(PTGS2)	0.074	.	0.17	***
M2 macrophage	CD163	0.903	***	0.83	***
	VSIG4	0.865	***	0.87	***
	MS4A4A	0.923	***	0.93	***
Dendritic Cells	HLA-DPB1	0.661	***	0.69	***
	HLA-DQB1	0.515	***	0.4	***
	HLA-DRA	0.698	***	0.71	***
	HLA-DPA1	0.696	***	0.7	***
	BDCA-1(CD1C)	0.46	***	0.45	***
	BDCA-4(NRP1)	0.587	***	0.64	***
	CD11c (ITGAX)	0.814	***	0.8	***
NK Cells	KIR2DL1	0.366	***	0.37	***
	KIR2DL3	0.326	***	0.46	***
	KIR2DL4	0.299	***	0.3	***
	KIR3DL1	0.286	***	0.35	***
	KIR3DL2	0.31	***	0.37	***
	KIR3DL3	0.077	.	0.048	.
	KID2DS4	0.253	***	–	–
T Cell (general)	CD3D	0.566	***	0.55	***
	CD3E	0.53	***	0.54	***
	CD2	0.652	***	0.67	***
Th1	T-bet (TBX21)	0.563	***	0.58	***
	STAT4	0.624	***	0.62	***
	STAT1	0.343	***	0.45	***
	IFN-γ (IFNG)	0.423	***	0.45	***
	TNF-α (TNF)	0.279	***	0.33	***
Th2	GATA3	0.417	***	0.44	***
	STAT6	0.019	.	0.016	**
	STAT5A	0.465	***	0.55	***
	IL13	0.133	**	0.19	***
Tfh	BCL6	0.3	***	0.4	***
	IL21	0.435	***	0.49	***
Th17	STAT3	0.365	***	0.45	***
	IL17A	0.007	.	0.031	.
Treg cells	FOXP3	0.562	***	0.59	***
	CCR8	0.665	***	0.71	***
	STAT5B	0.346	***	0.48	***
	TGF-β	0.453	***	0.5	***
Neutrophils	CD66B	0.064	.	0.069	.
	CD11b	0.784	***	0.77	***
	CCR7	0.492	***	0.51	***
Exhaustion T cells	TIM-3 (HAVCR2)	0.907	***	0.92	***
	TIGIT	0.57	***	0.6	***
	GZMA	0.553	***	0.56	***
	LAG-3	0.501	***	0.49	***
	CTLA4	0.478	***	0.54	***
	PD-1 (PDCD1)	0.467	***	0.49	***

TAMs – tumor-associated macrophages; NK cells – natural killer cells; Th1, Th2, Tfh, Th17 – helper T cell subtypes. P≥0.05,

^*P<0.05,

^**P<0.01,

^***P<0.001.