Table 3.

Cohort 2. Alzheimer’s disease (AD) group compared to controls, subjective cognitive decline (SCD), mild cognitive impairment (MCI) and non-AD groups combined. p values and Akaike information criterion (AIC) from binary logistic regression models. Area under the curve (AUC), 95% confidence intervals (95% CI) and differences between AUCs measured with DeLong test from receiver operating characteristic (ROC) analysis. APOE stands for presence of at least one APOE ε4 allele

	Cohort 2	p	AIC	AUC	95%CI	p value for difference with model containing N-224 alone
AD vs. controls, SCD, MCI and non-AD	N-224	< 0.0001	823	0.753	0.709–0.797	–
	Age	< 0.0001	830.9	0.659	0.603–0.715	0.007
	T-tau	< 0.0001	632.5	0.884	0.856–0.912	< 0.0001
	P-tau181	< 0.0001	601.8	0.894	0.865–0.923	< 0.0001
	N-224+T-tau	< 0.0001	666.9	0.886	0.859–0.913	< 0.0001
	N-224+P-tau181	< 0.0001	651.7	0.895	0.866–0.924	< 0.0001
	N-224+APOE	< 0.0001	807.3	0.784	0.749–0.820	ns
	Aβ42+P-tau181	< 0.0001	593.3	0.921	0.902–0.940	< 0.0001