Table 1.

Biophysical properties of WT and mutant channels

	CaV2.1 (Δ47)	Y1384C (Δ47)	CaV2.1 (+ 47)	Y1384C (+ 47)
V1/2, act (mV)	− 14.37 ± 0.85 n = 39	− 21.04 ± 1.57*** n = 29	− 15.14 ± 1.40 n = 22	− 21.13 ± 1.39* n = 14
k	− 3.68 ± 0.15	− 6.29 ± 0.51****	− 3.35 ± 0.23	− 6.18 ± 0.50****
V1/2, inac (mV)	− 39.85 ± 1.80 n = 10	− 47.54 ± 1.16* n = 13	− 39.18 ± 2.07 n = 11	− 50.10 ± 2.36** n = 10
k	7.56 ± 1.75	8.50 ± 2.14	7.17 ± 1.40	8.75 ± 1.67

One-way analysis of variance (ANOVA) and Tukey’s multiple comparation test, with a single pooled variance test was performed for multiple comparisons. Significance was established as follows: *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001