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. 2021 Feb 9;100(2):115338. doi: 10.1016/j.diagmicrobio.2021.115338

Table 2.

Severity of COVID-19 in patients with history of seasonal coronavirus (OC43, HKU1, 229E, and NL63) prior to COVID-19 pandemic.

Post-pandemic SARS-CoV-2
Mild Moderate/Severe Pvalue
Pre-pandemic seasonal CoV Northern California Positive 71.4% (5) 28.6% (2) 0.83
Negative 67.3% (33) 32.7% (16)
Washington Positive 33.3% (1) 66.7% (2) 0.75
Negative 25.0% (7) 75.0% (21)
Combined Positive 60.0% (6) 40.0% (4) 0.63
Negative 51.9% (40) 48.1% (37)