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. 2021 Feb 9;184(7):1858–1864.e10. doi: 10.1016/j.cell.2021.02.010

Figure 3.

Figure 3

SARS-CoV-2 infections boost antibodies that react to OC43 S protein

(A–D) We quantified antibody levels in serum collected from 27 individuals 0 and 7 days after hospitalization for COVID-19. ELISAs were completed to quantify levels of antibodies reactive to the S proteins of 229E, NL63, OC43, and SARS-CoV-2. IgG titers (A) and titer fold change (B) are shown. Levels of OC43 S-reactive antibodies (C) and fold change in OC43 S-reactive antibodies (D) were not associated with disease outcome. Paired t test of log2 transformed antibody titers, ∗∗∗∗p < 0.0001. One-way ANOVA Tukey’s multiple comparisons fold-change in antibody titers, ∗p < 0.04. Horizontal lines indicate the median and error bars show interquartile ranges. See also Figure S6.