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. 2021 Jan 26;10:603864. doi: 10.3389/fonc.2020.603864

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Copyright © 2021 Guo, Yang, Wang, Xu, Kou and Luo

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identification of a three-autophagy-related lncRNA prognostic signature. (A) Partial likelihood deviance was plotted versus log(λ). The vertical dotted line indicates the lambda value with the minimum error and the largest lambda value, where the deviance is within one standard error of the minimum. (B) LASSO coefficient profiles of genes associated with overall survival of head and neck squamous cell carcinoma. (C) Forest plot depicting associations between lncRNAs and risk value determined via multivariate Cox regression analysis. *p < 0.05, **p < 0.01. (D–F) Kaplan–Meier survival curves derived from three autophagy-related lncRNAs and HNSCC patients. These lncRNAs were considered to constitute a prognostic signature for HNSCC. AL121899.1 was identified as a negative prognostic factor, and TTTY15 and MIF-AS1 were identified as positive prognostic factors. (D) AL121899, (E) MIF-AS, (F) TTTY15.