Effect of temperature-dependent material properties. (a) Comparison of temperature profile in different points for constant and temperature-dependent material properties. Point 1 indicates the center of the nanoparticle. Point 2 indicates the location in medium that 15 nm from the surface of the particle. (b) Comparison of impact zones for constant and temperature-dependent material properties and the cytoplasm. The “constant properties” indicates results with constant water properties. Specifically, for cytoplasm as medium, the thermal conductivity of medium (km) is 0.57 W m−1 K−1, while other material properties are same as constant water properties. K(T), ρ(T), and Cp(T) indicate that thermal conductivity, density, and specific heat of materials are temperature dependent, respectively. The last group indicates results with temperature-dependences for all material properties ([k, ρ, Cp] (T)).