Figure 3.

Rate of intracranial metastatic disease (IMD) over time by disease site. (A) Timing of occurrence of brain metastasis since original primary cancer diagnosis. (B) Timing of occurrence of brain metastasis since original primary cancer diagnosis by disease site (logarithmic scale). For a given year, the number of brain metastases is equal to 2.23% of the number of incident cancer diagnosis occurring the previous year plus 1.07% of cases diagnosed the previous year, and so on. Disease-site specific estimates can be derived from the percentages in Supplementary Table S8. To permit sufficient follow-up across disease sites to develop IMD, only primary cancers diagnosed between 2010 and 2012 were included.