TABLE II.
Diverse Alu and Line dsRNAs stimulate IFN- and NF-κB responses
| Alu/Line class | genomic location | ISREa | NF-κBa |
|---|---|---|---|
| AluJb | chr17:76,418,582-76,418,856 | 0.3 | 1 |
| AluY2 | chr5:175,126,575-175,126,866 | 0.5 | 1 |
| AluJo | chr9:68,416,267-68,416,574 | 3 | 30 |
| AluJb | chr1:36,944,168-36,944,489 | 4 | >100 |
| AluSx1 | chr1:36,943,848-36,944,158 | 5 | >100 |
| AluSx3 | chr1:36,942,858-36,943,160 | 8 | >100 |
| AluY | chr3:71,827,084-71,827,387 | 20 | >100 |
| AluSp | chr15:74,893,758-74,894,053 | >100 | >100 |
| AluYk4 | chr12:51,711,490-51,711,800 | >100 | >100 |
| L5 | chr3:122,593,731-122,594,215 | 0.3 | 0.5 |
| L5-2 | chr2:197,877,529-197,878,005 | 0.5 | 0.5 |
| L1P1 | chr8:12,399,322-12,400,289 | 0.3 | 1 |
| L1PB1 | chr5:77462505-77463456 | 0.3 | 2 |
| L4 | chr7:36,559,566-36,560,029 | 0.3 | 3 |
| L4 | chr7:105,910,258-105,910,706 | 0.5 | 3 |
| L1MA4A | chr20:1,464,664-1,465,526 | 0.5 | 4 |
| L1PA3 | chr1:174,431,977-174,432,809 | 0.3 | 8 |
| L2a | chr6:24,920,947-24,921,396 | 0.5 | 10 |
| L2 | chr12:62,712,029-62,712,774 | 0.3 | 20 |
| L1P1 | chr16:31,910,131-31,910,962 | 1 | 30 |
| L1MA8 | chr6:11,274,877-11,275,769 | 2 | 40 |
| L3 | chrX:30,509,147-30,509,509 | 3 | 10 |
| L1PA4 | chr2:149,419,501-149,420,396 | 3 | 20 |
| L1PA2 | chr2:144,395,314-144,396,233 | 4 | 33 |
| L3 | chr13:100,034,217-100,034,854 | >100 | >100 |
| poly ICb | >100 | >100 |
a
Amount of the indicated RNAs required to stimulate a 10-fold increase in reporter activity compared to mock-transfected cell cultures.
b
Poly IC did not stimulate a 10-fold increase in secreted luciferase over unstimulated cell cultures at RNA amounts up to 100 ng.