Figure 6.

Anti-CD137 CAR-KHYG-1 cells specifically kill CD137-expressing RMS cells. 5000 RMS cells were co-cultured with KHYG-1 cells at a ratio of 1:10 for 24 h. The supernatants were collected for the measurement of LDH activities and cytokine levels. (a) Percentages of RMS cell lysis (b) IFNγ level (c) TNF level. Top row: Rd18 cells, bottom row: Rh41 cells. Results are pooled from three independent experiments and presented as means ± standard errors of means. ** p < .01 using two-sided unpaired t-test