Figure 1.

The chronic effect of Ang II on I_Ks current in HEK 293B cell. (a) The representative I_Ks current evoked by voltage protocol shown in inset under the Ang II (100 nM) treatment. (b) The current–voltage relationship for the tail currents under the Ang II (100 nM) treatment. (c) The summary data for the tail currents under the Ang II (100 nM) treatment at +40 mV prepulse. (d) The normalized I–V relationship for I_Ks current. The solid lines represent fits to a Boltzmann function. (e) The representative immunoblot and summary data for the KCNQ1 channel membrane protein under the Ang II (100 nM) treatment (**P < 0.01, compared with the control group; ^##P < 0.01, compared with the Ang II treatment group)