Table 3.

IPD distribution and Resistance rate of Non-PCV7/13 serotypes

	Children							Adults
	Susceptibility n = 63		IPD (n = 58)					Susceptibility n = 107		IPD (n = 94)
Non-PCV7Serotype	TX	MP	Pneumonia	Sepsis	Meningitis	Bacteremia	Other	TX	MP	Pneumonia	Meningitis	Bacteremia	Sepsis	Other
19A	15/31(48.4)	26/31(83.9)	14/29(48.3)	8/29(27.6)	4/29(13.8)	1/29(3.4)	2/29(6.9)	3/16(18.8)	14/16(87.5)	5/13(38.5)	3/13(23.1)	2/13(15.4)	0/13(0.0)	3/13(23.1)
6A	1/7(14.3)	6/7(85.7)	0/6(0.0)	2/6(33.3)	2/6(33.3)	0/6(0.0)	2/6(33.3)	0/6(0.0)	1/6 (16.7)	2/3(66.7)	1/3(33.3)	0/3(0.0)	0/3(0.0)	0/3(0.0)
3	0/5(0.0)	1/5(20.0)	0/4(0.0)	3/4(75.0)	1/4(25.0)	0/4(0.0)	0/4(0.0)	1/33(3.0)	3/33(9.1)	12/28(42.9)	3/28(10.7)	6/28(21.4)	4/28(14.3)	3/28(10.7)
20	0/1(0.0)	0/1(0.0)	1/1(100.0)	0/1(0.0)	0/1(0.0)	0/1(0.0)	0/1(0.0)	0/6(0.0)	0/6(0.0)	3/6(50.0)	2/6(33.3)	0/6(0.0)	0/6(0.0)	1/6(16.7)
Other	4/19(21.1)	7/19(36.8)	3/18(16.7)	11/18(61.1)	2/18(11.1)	0/18(0.0)	2/18(11.1)	2/46(4.3)	6/46(13.0)	16/44(36.4)	8/44(18.2)	7/44(15.9)	8/44(18.2)	5/44(11.4)
	Susceptibility n = 15		IPD (n = 15)					Susceptibility n = 45		IPD (n = 43)
Non-PCV13Serotype	TX	MP	Pneumonia	Sepsis	Meningitis	Bacteremia	Other	TX	MP	Pneumonia	Sepsis	Meningitis	Bacteremia	Other
20	0/1(0.0)	0/1(0.0)	1/1(100.0)	0/1(0.0)	0/1(0.0)	0/1(0.0)	0/1(0.0)	0/6(0.0)	0/6(0.0)	3/6(50.0)	0/6(0.0)	2/6(33.3)	0/6(0.0)	1/6(16.7)
15 C	0/3(0.0)	2/3(66.7)	1/3(33.3)	2/3(66.7)	0/3(0.0)	0/3(0.0)	0/3(0.0)	0/2(0.0)	1/2(50.0)	1/2(50.0)	0/2(0.0)	0/2(0.0)	1/2(50.0)	0(0.0)
23A	0/2(0.0)	0/2(0.0)	1/2(50.0)	0/2(0.0)	0/2(0.0)	0/2(0.0)	1/2(50.0)	0/2(0.0)	1/2(50.0)	1/2(50.0)	0/2(0.0)	1/2(50.0)	0/2(0.0)	0/2(0.0)
Other	2/9(22.2)	3/9(33.3)	1/9(11.1)	5/9(55.6)	2/9(22.2)	0/9(0.0)	1/9(11.1)	1/35(2.2)	5/45(9.1)	13/33(39.4)	7/33(21.2)	3/33(9.1)	5/33(15.2)	5/33(15.2)

Data are expressed as n(%); non-PCV7 isolates: 170; non-PCV13 isolates: 60; MIC₉₀ (range) for non-PCV7 isolates (mg/L) – TX: 2 (0.002, 32) in children and 1 (0.002, 2) in adults; MP: 0.75 (0.003, 6) in children and 2 (0.002, 4) in adults; MIC₉₀ (range) for non-PCV13 isolates (mg/L) – TX: 2 (0.002, 3) in children and 0.6 (0.002, 1) in adults; MP: 1.9 (0.003, 4) in children and 3.4 (0.003, 4) in adults;

Most clinically significant IPDs were listed; Individual serotypes accounted for >1.0% or n ≥ 4 for non-PCV7 or non-PCV13 in the pediatric or adult group were displayed; IPD was deemed as the primary diagnosis of the invasive disease caused by S. pneumoniae infections;

IPD: invasive pneumococcal disease; TX: ceftriaxone parenteral; MP: meropenem