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CRS induced disrupted neurotransmitter metabolism in Trp pathway in the brain and serum. Differences in Trp and its metabolites in the (a) PFC, (b) hippocampus and (c) serum are shown. Values represent the mean ± S.E.M. of 10 animals per group. *p < .05 and **p < .01 indicate significant differences vs. the CTL+PBS group, and #p < .05 and ##p < .01 indicate significant differences vs. the CRS+PBS group
