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. 2021 Jan 21;8:618552. doi: 10.3389/fcell.2020.618552

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Copyright © 2021 Ostrop, Zwiggelaar, Terndrup Pedersen, Gerbe, Bösl, Lindholm, Díez-Sánchez, Parmar, Radetzki, von Kries, Jay, Jensen, Arrowsmith and Oudhoff.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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BET inhibition reduces relative abundance of tuft cells. (A) Gene expression of tuft cell marker genes of organoids treated with DMSO, (+)-JQ1, or bromosporine for 96 h, measured by qRT-PCR. xfold change relative to DMSO-treated organoids. 4 biol. replicates, indicated by shape. Median highlighted. Paired t-test. (B) Representative Hpgds-tdTomato tuft cell reporter organoids treated with DMSO, (+)-JQ1, or bromosporine for 8 days with one passage. 10x magnification, max. intensity projection. (C) Tuft cell density in Hpgds-tdTomato organoids with DMSO, (+)-JQ1, or bromosporine for 8 days. Each dot represents one organoid. Unpaired t-test.