Fig 1.

Dose response of GSK2593074A (GSK’074) on aneurysm formation. A, Experimental design. C57BL/6J mice underwent daily intraperitoneal injections with dimethylsulfoxide (DMSO)-control or GSK’074 (0.31, 0.93, 2.33, or 4.65 mg/kg), starting at the time of aneurysm induction by calcium phosphate model. B, Mice were humanely killed 14 days after aneurysm induction and percentage increase in maximal external aortic diameter measured by digital caliper was calculated. C, Representative images of aortas. n = 5 for each group. One-way analysis of variance with a post hoc Tukey's test was performed. ∗P ≤ .05. The bars indicate 95% confidence intervals. AAA, Abdominal aortic aneurysm.