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. 2020 Jun 4;13(3):438–458. doi: 10.1037/pne0000221

Figure 1.

Figure 1

Experimental design—serial visual reversal learning. Panel A: Timeline of the touchscreen serial visual reversal learning experiment involving behavioral training, surgery, and behavioral testing with intracerebral infusions of DHK or M100907. Panel B: Timeline of one of the 2 (DHK) or 3 (M100907) weeks of reversal learning testing with drug or vehicle infusions. Panel C: Flowchart of possible trial sequences in the touchscreen visual discrimination and reversal learning task. Panel D: Schematic representation of brain sections showing the infusion sites in the mOFC (DHK, N = 8), lOFC (DHK, N = 8), mOFC (M100907, N = 9), and lOFC (M100907, N = 13) included in the reversal learning analyses. Infusion sites were characterized from brain sections prepared with cresyl violet. Coordinates are given as millimeter distance from bregma. CS = conditioned stimulus; ITI = intertribal interval or intertrial interval; VD = visual discrimination.