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. Author manuscript; available in PMC: 2021 Feb 9.
Published in final edited form as: Neurogastroenterol Motil. 2020 Apr 15;32(7):e13853. doi: 10.1111/nmo.13853

Figure 2. Recording and analysis of compound nerve action potential (CNAP).

Figure 2.

To record CNAP, a bipolar recording cuff electrode was placed about 3mm below (A) or above (B) the bipolar stimulation cuff electrode. The stimulus parameter was set at pulse amplitude = 0.6mA, pulse width = 0.5ms, and pulse frequency = 10Hz. A train (20s) of cathode-first, alternating-monophasic pulses was delivered to the nerve. The time series represent the averaged response waveform from each of the 3 animals. The yellow dashed box indicates the stimulus artifact. The red arrow indicates the visually identified peak response of VNS-evoked CNAP. When the stimulation cuff electrode was placed rostral to the recording cuff electrode, the amplitude of evoked nerve potential was greater under efferent VNS than afferent VNS. When the stimulation cuff electrode was placed caudal to the recording cuff electrode, the amplitude of evoked nerve potential was greater under afferent VNS than efferent VNS.