TABLE 1.
Demographics
| Group | Overall | A | B | P |
|---|---|---|---|---|
| n | 13 | 6 | 7 | |
| Demographics | ||||
| Age, mean y (SD) | 43.07 (11.60) | 36.18 (7.32) | 48.97 (11.68) | .041 |
| Female, n (%) | 9 (69.2) | 3 (50.0) | 6 (85.7) | .431 |
| Black/African American, n (%) | 4 (30.8) | 1 (16.7) | 3 (42.9) | .676 |
| Etiology of ESRD, n (%) | ||||
| Hypertension, n (%) | 2 (15.4) | 0 (0.0) | 2 (28.6) | .439 |
| Glomerulonephritis/glomerular disease, n (%) | 1 (7.7) | 0 (0.0) | 1 (14.3) | |
| Systemic lupus erythematosus, n (%) | 2 (15.4) | 1 (16.7) | 1 (14.3) | |
| Obstructive disorder/reflux, n (%) | 1 (7.7) | 1 (16.7) | 0 (0.0) | |
| Renal hyperplasia/dysplasia, n (%) | 1 (7.7) | 1 (16.7) | 0 (0.0) | |
| Alport syndrome, n (%) | 1 (7.7) | 1 (16.7) | 0 (0.0) | |
| Dysplastic kidneys, n (%) | 2 (15.4) | 1 (16.7) | 1 (14.3) | |
| Lupus nephritis, n (%) | 1 (7.7) | 0 (0.0) | 1 (14.3) | |
| Unknown, n (%) | 1 (7.7) | 1 (16.7) | 0 (0.0) | |
| Other, n (%) | 1 (7.7) | 0 (0.0) | 1 (14.3) | |
| Coronary artery disease, n (%) | 1 (7.7) | 1 (16.7) | 0 (0.0) | .936 |
| Hypertension, n (%) | 11 (84.6) | 4 (66.7) | 7 (100.0) | .374 |
| Hyperlipidemia, n (%) | 4 (30.8) | 2 (33.3) | 2 (28.6) | >.999 |
| Diabetes, n (%) | 2 (15.4) | 1 (16.7) | 1 (14.3) | >.999 |
| Receiving dialysis, n (%) | 13 (100.0) | 6 (100.0) | 7 (100.0) | NA |
| Peritoneal dialysis, n (%) | 2 (15.4) | 0 (0.0) | 2 (28.6) | .514 |
| Time on dialysis, y, mean (SD) | 6.16 (3.82) | 4.66 (3.05) | 7.44 (4.15) | .204 |
| Sensitization history | ||||
| Prior transplant, n (%) | 10 (76.9) | 5 (83.3) | 5 (71.4) | >.999 |
| Number of prior transplants, median [IQR] | 1.00 [1.00, 1.00] | 1.00 [1.00, 1.00] | 1.00 [1.00, 1.00] | .317 |
| Type of prior transplant, n (%) | ||||
| Deceased donor kidney transplant, n (%) | 5 (50.0) | 2 (40.0) | 3 (60.0) | .549 |
| Living-unrelated kidney transplant, n (%) | 1 (10.0) | 1 (20.0) | 0 (0.0) | |
| Living-related kidney transplant, n (%) | 4 (40.0) | 2 (40.0) | 2 (40.0) | |
| Etiology of transplant failure, n (%) | ||||
| Acute AMR | 1 (10.0) | 1 (20.0) | 0 (0.0) | .549 |
| Chronic rejection | 4 (40.0) | 2 (40.0) | 2 (40.0) | |
| Transplant glomerulopathy | 1 (10.0) | 1 (20.0) | 0 (0.0) | |
| Recurrent disease | 1 (10.0) | 0 (0.0) | 1 (20.0) | |
| Polyoma (BK) nephropathy | 1 (10.0) | 0 (0.0) | 1 (20.0) | |
| Other | 2 (20.0) | 1 (20.0) | 1 (20.0) | |
| Transplant nephrectomy, n (%) | 3 (23.1) | 0 (0.0) | 3 (42.9) | .243 |
| Pregnancy, n (%) | 6 (66.7) | 2 (66.7) | 4 (66.7) | >.999 |
| Blood transfusion, n (%) | 6 (46.2) | 1 (16.7) | 5 (71.4) | .157 |
| cPRA1500, MFI, mean (SD) | 92.90 (19.47) | 87.89 (28.74) | 97.19 (4.83) | .414 |
| cPRA1500, median [IQR] | 99.89 [98.53, 99.99] | 99.80 [98.82, 99.94] | 99.97 [96.23, 99.99] | .616 |
| cPRA4000, MFI, mean (SD) | 84.52 (29.56) | 80.62 (39.67) | 87.86 (20.20) | .679 |
| cPRA4000, median [IQR] | 97.50 [89.80, 99.94] | 97.10 [91.53, 99.17] | 99.88 [84.05, 99.96] | .568 |
| cPRA8000, MFI, mean (SD) | 74.89 (34.70) | 69.81 (40.63) | 79.24 (31.37) | .646 |
| cPRA8000, median [IQR] | 93.03 [59.39, 99.23] | 89.90 [52.35, 96.91] | 98.90 [69.83, 99.56] | .475 |
cPRA, calculated panel reactive antibody; ESRD, end-stage renal disease; MFI, mean fluorescence intensity.