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. 2021 Jan 28;17(1):e1009261. doi: 10.1371/journal.ppat.1009261

Fig 10. A schematic diagram depicting PF-8-induced PARP1 degradation via recruitment of CHFR to promote KSHV lytic replication.

Fig 10

(A) PARP1 interacts with RTA and inhibits RTA function through PARylation of RTA. Lytic replication is under repression. (B) PF-8 is expressed as an early gene product of KSHV lytic genes. PF-8 interacts with CHFR, an E3 ligase, and recruits it to target PARP1, and resulted in polyubiquitination and degradation of PARP1. PF-8-induced PARP1 degradation derepresses the RTA activity and promotes efficient lytic replication of KSHV.