Table 1.

Cognitive performance predicted by ROI

ROI	VCI			PRI			WMI			PSI
	beta†	t (df)	P	beta†	t (df)	P	beta†	t (df)	P	beta†	t (df)	P
ICV	−0.3	−0.22 (112)	0.823	1.72	1.16 (111)	0.25	0.5	0.33 (112)	0.744	−0.44	−0.29 (112)	0.773
Frontal Lobe GM	1.54	0.19 (112)	0.851	7.15	0.87 (111)	0.385	−11.38	−1.28 (112)	0.204	−4.37	−0.49 (112)	0.623
Frontal Lobe WM	12.43	1.6 (112)	0.112	10.56	1.17 (111)	0.234	−1.97	−0.22 (112)	0.827	1.58	0.18 (112)	0.86
Parietal Lobe GM	0.93	0.06 (112)	0.949	9.97	0.67 (111)	0.504	−2.86	−0.18 (112)	0.86	9.57	0.63 (112)	0.53
Caudate	−691.21	−2.33 (112)	0.022 *	−285.26	−0.84 (111)	0.4	−776.27	−2.41 (112)	0.017 *	−176.32	−0.52 (112)	0.604
Putamen	−87.96	−0.37 (112)	0.715	61.09	0.23 (111)	0.815	−125.84	−0.5 (112)	0.618	−266.31	−1.06 (112)	0.29
Accumbens	−612.51	−0.38 (112)	0.707	1327.12	0.71 (111)	0.477	59.5	0.03 (112)	0.973	−2164.56	−1.26 (112)	0.21
Thalamus	123.87	0.83 (112)	0.409	−105.72	0.63 (111)	0.528	204.68	1.25 (112)	0.215	18.97	0.11 (112)	0.91
Hippocampus	−286.2	−1.02 (112)	0.310	−854.4	−2.82 (111)	0.006 **	−387.8	−1.27 (112)	0.205	−867.32	−2.87 (112)	0.005 **
Amygdala	184.8	0.18 (112)	0.858	−441.54	−0.39 (111)	0.698	−1073.94	−0.96 (112)	0.337	−1591.96	−1.47 (112)	0.144
Corpus Callosum	805.59	1.64 (112)	0.105	1143.77	2.04 (111)	0.044 *	−72.81	−0.13 (112)	0.898	−190.95	−0.32 (112)	0.751

Note: beta† indicates estimated values for age and sex-adjusted interaction effect of Wechsler Adult Intelligence Scale 4^th Edition (WAIS-IV) cognitive performance predicted by region of interest (ROI) volume.

Abbreviations: VCI, Verbal Comprehension Index; PRI, Perceptual Reasoning Index; WMI, Working Memory Index; PSI, Processing Speed Index

^*P < 0.05

^**P < 0.01