Figure 4.

Heatmap of 49 drug associations across the COVID-19 severity scale: hospitalized-mild (M), ICU admission (I), on ventilation (V), and death (D). In Figures 4A and 4B the secondary outcomes were extracted following the cumulative severity and exclusive severity strategies, respectively. In Figure 4B, drug studies that did not meet the inclusion criteria are shown in white.

Abbreviations: *A Streptococcus pneumoniae serotype X: Streptococcus pneumoniae serotype (1, 19A, 3, 5, 6A, 7F) capsular antigen diphtheria CRM197 protein conjugate vaccine; *B Streptococcus pneumoniae serotype X: Streptococcus pneumoniae serotype (14, 18C, 19F, 23F, 4, 6B, 9V) capsular antigen diphtheria CRM197 protein conjugate vaccine; *C Streptococcus pneumoniae type X: Streptococcus pneumoniae type (1, 10A, 11A, 12F, 14, 15B, 17F, 18C, 19A, 19F, 2, 20, 22F, 23F, 3, 33F, 4, 5, 6B, 7F, 8, 9N, 9V) capsular polysaccharide antigen