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. Author manuscript; available in PMC: 2021 Jul 1.
Published in final edited form as: Kidney Int. 2020 Feb 22;98(1):76–87. doi: 10.1016/j.kint.2020.01.036

Figure 3. MNP-ODN2088-mediated reduction of renal tubular necrosis after ischemic AKI.

Figure 3.

Representative H&E images (from 4–7 experiments) of kidneys from mice injected with control MNPs or with MNP-ODN2088 and subjected to sham surgery (N=4) or to 30 min renal ischemia and 24 hrs reperfusion (N=6–7, magnification 200X). Some mice were injected with MNP-ODN2088 6 hr before renal ischemia. A separate cohort of mice was injected with MNP-ODN2088 at the time of reperfusion or 1.5 hr after reperfusion. Another cohort of mice were injected with 5 mg/kg naked ODN2088 i.v. 6 hr before renal ischemia (N=5–6). Renal injury scores assessing the degree of renal tubular necrosis are also shown here (scale: 0–4) 24 hrs after renal IR. *P<0.05 vs. control MNP injected mice subjected to renal IR injury. For statistical analysis, the Mann–Whitney nonparametric test was used to detect significant changes.