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The left side of the figure shows non-amyloid-forming reactions in which APP is cleaved by α-secretase to form sAPP-α, then by γ-secretase to yield P3 and AICD (amyloid intracellular domain). The right side of the figure shows amyloid-forming reactions in which APP is cleaved by BACE1 to form sAPP-β, then by γ-secretase to yield Aβ and AICD
