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The two predicted topologies of the coronavirus membrane (M). (A) In the first prediction, the M has three transmembrane domains (TMDs) located within the viral envelope. In this topology of the coronavirus M, the N-terminus domain (NTD) is found on the outside of the virion envelope and the C-terminus domain (CTD) on the inside of the virion. (B) In the second prediction, the M is presented with both the NTD and CTD at the outer surface of the virion. The TMDs are labeled 1–4.
