Table 1. External validation of the SuperSigs using the ICGC database.
Cross-validated performances (AUCs) of the indicated SuperSigs on TCGA data, compared to their performance when then used as predictors on ICGC data. The number n of samples tested for each combination of tumor type and factor is indicated in parenthesis.
| Tissue | Factor | TCGA | ICGC |
|---|---|---|---|
| CHOL | AGE | 0.73 (n = 26) | 0.66 (n = 35) |
| HNSCC | AGE | 0.73 (n = 120) | 0.80 (n = 9) |
| KIRC | AGE | 0.81 (n = 123) | 0.75 (n = 82) |
| LIHC | AGE | 0.70 (n = 57) | 0.66 (n = 208) |
| OV | AGE | 0.71 (n = 87) | 0.87 (n = 92) |
| PAAD | AGE | 0.65 (n = 35) | 0.66 (n = 203) |
| PRAD | AGE | 0.65 (n = 305) | 0.83 (n = 120) |
| SKCM | AGE | 0.61 (n = 82) | 0.45 (n = 47) |
| STAD | AGE | 0.66 (n = 176) | 0.64 (n = 21) |
| LIHC | ALCOHOL | 0.62 (n = 154) | 0.66 (n = 25) |
| HNSCC | SMOKING | 0.81 (n = 354) | 0.78 (n = 13) |