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. Author manuscript; available in PMC: 2021 Feb 9.
Published in final edited form as: Biochemistry. 2020 Sep 10;59(38):3594–3614. doi: 10.1021/acs.biochem.0c00576

Figure 1.

Figure 1.

GPR68 snake model and partial sequence alignment to highlight the Histidine (H) in this study. (a) Histidine (H) residues are highlighted and mutated in this project, H17 and H20 in the N-terminal, H84 and H89 in the first extracellular loop (ECL1), H159 at the top of transmembrane helix 4 (TM IV), H169 and H175 in ECL2, H245 in TM VI, and H269 in TM VII. The model is modified based on the GPR68 model from gpcrdb.org. (b) Partial sequence alignment illustrates the extracellular Histidine (H) residues in GPR4, GPR65, and GPR68.