Figure 5.

Bixin blunts hepatosteatosis and reduces circulating lipid levels in HFD-fed mice through Nrf2 signals. (a) Schematic representation of HFD feeding and bixin administration duration in Nrf2 WT and KO mice. (b) Food consumption, (c) water consumption, (d) BW, (e) LW/BW, (f) liver TG content, (g) liver TC content, (h) serum TG, (i) serum TC, (j) serum LDL, (k) serum HDL, (l) serum ALT, and (m) serum AST of mice with the indicated treatments are provided. Results are expressed as the means ± SD (n = 10; ^∗p < 0.05, Ctrl vs. treatment groups; ^#p < 0.05, HFD group vs. HFD+bixin group). (n) Liver tissue sections from different groups of Nrf2 WT and Nrf2 KO mice were subjected to Oil Red O staining (n = 10; scale bar = 100 μm. Representative images from each group are shown).