Table 1.
Treatment | Dose (mg/kg) | Period (week) | ||||||
---|---|---|---|---|---|---|---|---|
0 | 1 | 2 | 3 | 4 | 5 | 6 | ||
Normal control | — | 106.67 ± 3.24 | 104.27 ± 2.18 | 109.07 ± 5.05 | 107.67 ± 3.62 | 104.67 ± 3.93 | 105.57 ± 2.99 | 106.40 ± 4.01 |
| ||||||||
Diabetic control | — | 104.06 ± 2.82 | 380.20 ± 8.50λ | 440.03 ± 18.27λ | 446.50 ± 17.88λ | 445.03 ± 20.59λ | 448.23 ± 18.13λ | 456.50 ± 14.27λ |
| ||||||||
Pregabalin | 30 | 109.67 ± 4.91 | 381.00 ± 8.65λ | 434.50 ± 24.89λ | 358.33 ± 13.04λc | 354.33 ± 9.28λc | 357.83 ± 13.19λc | 352.13 ± 11.73λc |
| ||||||||
Aqueous extract | 150 | 107.67 ± 0.95 | 376.00 ± 16.17λ | 438.50 ± 16.55λ | 258.31 ± 16.70λc | 168.00 ± 8.75c | 161.67 ± 5.25c | 136.67 ± 6.07c |
300 | 104.83 ± 1.49 | 366.67 ± 10.18λ | 454.34 ± 18.21λ | 224.88 ± 6.88λc | 133.33 ± 5.50c | 124.50 ± 4.28c | 117.50 ± 5.06c | |
| ||||||||
Methanol extract | 150 | 105.33 ± 1.61 | 396.00 ± 11.55λ | 448.04 ± 12.59λ | 285.17 ± 4.07λc | 190.02 ± 19.18c | 176.83 ± 11.03c | 140.17 ± 6.47c |
300 | 106.83 ± 1.47 | 391.21 ± 12.57λ | 444.18 ± 16.76λ | 245.19 ± 13.78λc | 161.27 ± 14.06c | 152.18 ± 14.46c | 130.22 ± 8.94c |
All values are expressed as the mean ± SEM of six animals per experimental group, compared by one-way analysis of variance followed by Tukey test; λp <0.001 means significantly different from the normal control group (nondiabetic); and cp <0.001 means significantly different from the diabetic control group.